Crystal-Seeded Growth of pH-Responsive Metal–Organic Frameworks for Enhancing Encapsulation, Stability, and Bioactivity of Hydrophobicity Compounds

Liu, Z., Wu, Q., He, J., Vriesekoop, F. and Liang, H. (2019) Crystal-Seeded Growth of pH-Responsive Metal–Organic Frameworks for Enhancing Encapsulation, Stability, and Bioactivity of Hydrophobicity Compounds. ACS Biomaterials Science & Engineering, 5 (12). pp. 6581-6589.

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Abstract

Zeolitic imidazolate framework-L (ZIF-L) could effectively improve the stability, controlled release, and anticancer activity of natural hydrophobicity drugs in drug delivery systems (DDSs). A simple and universal strategy was developed to prepare the curcumin-loaded ZIF-L (CCM@ZIF-L) by the antisolvent coprecipitation method, which was different from the traditional approaches. The microcrystal molecules of curcumin were used as the core of ZIF-L growth to form CCM@ZIF-L, which has a very high drug encapsulation efficiency of 98.21% and a regular leaf or cruciate flower-like structure. The formation of CCM@ZIF-L with a distinct composite structure was supported by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared, powder X-ray diffraction, and zeta-potential. Because of the protective effect of ZIF-L, CCM@ZIF-L exhibited excellent stability and about a 5-fold increase in temperature stability over free curcumin. CCM@ZIF-L exhibited controlled drug release behavior in simulated in vitro tumor microenvironments (almost 81.2% drug release over a period of 72 h). Furthermore, confocal laser scanning microscopy results and cytotoxicity experiments confirmed that the encapsulated curcumin showed a significant improvement in cellular uptake and anticancer activity against A549 cancer cells. Moreover, the curcumin encapsulated in ZIF-L exhibited remarkable cellular antioxidant activity based on MGC-803 cell models. This work presents a novel approach to solve the drug loading problem by employing ZIF-L and exhibits enormous potential of ZIF-L as an effective DDS in cancer treatments.

Item Type: Article
Keywords: ZIF-L, microcrystal of curcumin, pH-responsive, drug delivery, cancer treatment
Divisions: Food Science and Agri-food Supply Chain Management
Depositing User: Ms Kath Osborn
Date Deposited: 09 Jan 2020 10:25
Last Modified: 09 Jan 2020 10:25
URI: http://hau.repository.guildhe.ac.uk/id/eprint/17489

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