Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes
Theodorou, M.K., Solomon, K.V., Haitjema, C.H., Henske, J.K., Gilmore, S.P., Borges-Rivera, D., Lipzen, A., Brewer, H.M., Purvine, S.O., Wright, A.T., Grigoriev, I.V., Regev, A., Thompson, D.A. and O'Malley, M.A. (2016) Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes. Science, 351 (6278). pp. 1192-1195.
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Mike Theodorou Early-branching gut fungi upload 9 Feb 2016.pdf - Accepted Version Download (1MB) | Preview |
Abstract
The fungal kingdom is the source of almost all industrial enzymes in use for lignocellulose bioprocessing. We developed a systems-level approach that integrates transcriptomic sequencing, proteomics, phenotype, and biochemical studies of relatively unexplored basal fungi. Anaerobic gut fungi isolated from herbivores produce a large array of biomass-degrading enzymes that synergistically degrade crude, untreated plant biomass and are competitive with optimized commercial preparations from Aspergillus and Trichoderma. Compared to these model platforms, gut fungal enzymes are unbiased in substrate preference due to a wealth of xylan-degrading enzymes. These enzymes are universally catabolite-repressed and are further regulated by a rich landscape of noncoding regulatory RNAs. Additionally, we identified several promising sequence-divergent enzyme candidates for lignocellulosic bioprocessing.
| Item Type: | Article |
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| Keywords: | gut fungi, basal fungi, biomass |
| Divisions: | Animal Production, Welfare and Veterinary Sciences (to 31.07.20) |
| Depositing User: | Ms Kath Osborn |
| Date Deposited: | 07 Jun 2016 13:21 |
| Last Modified: | 23 Jan 2018 12:14 |
| URI: | https://hau.repository.guildhe.ac.uk/id/eprint/9262 |
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